Calcium Ionophore A23187 Calimycin
Price range: $418.00 through $3,018.00
Catalog No: SP-I-0036
Purity: 98%+
CAS No: 52665-69-7
Synonyms: Calcimycin, Antibiotic A 23187, Calimycin
MW: 523.62
Formula: C29H37N3O6
Calcium Ionophore A23187 is a carboxylic acid ionophore that facilitates the transport of divalent cations such as calcium and magnesium across biological membranes increasing their solubility in organic solvents It is widely used in calcium signaling oxidative phosphorylation and apoptosis research making it a key tool in cell biology and biochemical studies
Key Features and Benefits
Highly selective for calcium enhancing calcium influx and intracellular modulation
Induces cellular responses including Toxoplasma eIF2 alpha phosphorylation and nitric oxide production
Functions as an oxidative phosphorylation uncoupler and ATPase inhibitor for mitochondrial research
Used for oocyte activation and acrosome reaction in assisted reproductive technologies and sperm physiology studies
Long term stability at minus twenty degrees Celsius when protected from light and moisture ensuring reliability in research applications
Applications
Used in endoplasmic reticulum stress studies examining unfolded protein response gene expression in Toxoplasma
Applied in neuroscience and NMDA receptor research potentiating NMDA responses without affecting quisqualate receptors
Used in apoptosis and cell death studies showing dual roles in either inducing or inhibiting apoptosis depending on cellular context
Employed in SERCA activity assays evaluating sarcoplasmic reticulum calcium ATPase function in muscle physiology
Storage and Solubility
Store at minus twenty degrees Celsius protected from light and moisture for maximum stability
Soluble in DMSO ethanol and organic solvents stable for at least three months under proper storage conditions
References
Jing Yuan et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, 5(10), 765-771; DOI: 10.1038/nchembio.215
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